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Regis Whelk-O Chiral Column

Updated: Jun 17, 2021

This chiral phase is compatible with all commonly used mobile phases, including aqueous systems—a distinct advantage over coated polysaccharide CSP.

The Whelk-O® 1 is useful for the separation of underivatized enantiomers in a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, alcohols, and non-steroidal anti-inflammatory drugs (NSAIDs).

The Whelk-O 1 Chiral Stationary Phase is based on 1-(3,5-Dinitrobenzamido)- 1,2,3,4,-tetrahydrophenanthrene.

Recognized as USP L102.


Regis Whelk O1


This π-electron acceptor/ π-electron donor phase exhibits an extraordinary degree of generality. The broad versatility observed on the Whelk-O® 1 column compares favorably with polysaccharidederived chiral stationary phases. In addition, because Whelk-O® 1 is covalently bonded to the support, the phase is compatible with all commonly used mobile phases, including aqueous systems — a distinct advantage over polysaccharide derived chiral stationary phases. Other advantages include column durability, excellent efficiency, ability to invert elution order, and excellent preparative capacity.


Regis Whelk O2


The newest addition to the Whelk-O® line of chiral stationary phases is the Whelk-O® 2. The Whelk-O® 2 is the covalent trifunctional version of the Whelk-O® 1. The Whelk-O® 2 retains the same chiral selector but incorporates a trifunctional linkage to the silica support. In most cases, the enantioselectivity remains the same as that obtained with the Whelk-O® 1. Whelk-O® 2 was designed to improve the resistance of the stationary phase to hydrolysis while using strong organic modifiers such as trifluoroacetic acid. The Whelk-O® 2 is ideal for preparative separations since the material is bonded on 10 µm, 100Å spherical Kromasil silica. This allows the preparative chromatographer to perform method development on an analytical column and immediately scale up to larger diameter columns.

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