Regis Chiral Column

Polysaccharide chiral columns are the most widely used type of chiral stationary phases (CSPs) to separate enantiomers. Regis Reflect™ chiral columns are rugged polysaccharide phases suitable for a wide range of chiral compounds. Unique, proprietary, phase coverage provides excellent peak shape and improved resolution versus leading chiral phases. High resolution greatly improves preparative loading, leading to greater productivity and higher purity separations. Combined with attractive pricing and rapid delivery, Reflect™ chiral columns deliver the performance and productivity you expect. Reflect™ columns are available packed with immobilized and coated CSPs.

 
Immobilized Chiral Column

Reflect polysaccharide immobilized chiral columns are made using a unique production process of immobilizing the chiral selector on high purity silica gel. Immobilizing the selector improves the stability of the chiral phase and broadens the range of mobile phase options.

  • Rugged, immobilized phase for long column lifetimes

  • High-efficiency media with excellent peak shape and loading capacity

  • Compatible with a broad range of solvents and separation modes (NP, RP, Polar Organic, SFC)

  • Fully scalable from 3-20 μm

I-Amylose A & I-Cellulose B
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tris (3,5- dimethylphenylcarbamate)

I-Cellulose C
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tris (3,5- dichlorophenylcarbamate)

I-Cellulose J
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tris (4-methylbenzoate)

Coated Chiral Column

Reflect polysaccharide coated chiral columns are made using a unique production process of coating the chiral selector on high purity silica gel. Reflect chiral phases have been developed to match or exceed the performance of legacy polysaccharide chiral columns.

  • High-efficiency media with excellent peak shape and loading capacity

  • Compatible with a wide range of solvents and separation modes (normal phase HPLC and SFC)

  • Fully scalable from 3-20 μm

Amylose tris(3,5-dimethylphenylcarbamate)

Reflect C-Amylose A is categorized as USP Code L51.

Reflect™ coated amylose chiral columns are high performance polysaccharide chiral phases suitable for a wide range of chiral compounds in normal phase HPLC and SFC modes. Unique, proprietary, phase coverage provides excellent peak shape and improved resolution versus leading chiral phases. This high resolution greatly improves preparative loading, leading to greater productivity and higher purity separations. Combined with attractive pricing and rapid delivery, Reflect chiral columns deliver the performance and productivity you expect.

Reflect coated phases are available in a range of particle sizes, allowing analytical scale separations up through large scale preparative separations.

Cellulose tris(3,5-dimethylphenylcarbamate)

Reflect C-Cellulose B is categorized as USP Code L40.

Reflect™ coated cellulose chiral columns are high performance polysaccharide chiral phases suitable for a wide range of chiral compounds in normal phase HPLC and SFC modes. Unique, proprietary, phase coverage provides excellent peak shape and improved resolution versus leading chiral phases. This high resolution greatly improves preparative loading, leading to greater productivity and higher purity separations. Combined with attractive pricing and rapid delivery, Reflect chiral columns deliver the performance and productivity you expect.

Reflect coated phases are available in a range of particle sizes, allowing analytical scale separations up through large scale preparative separations.

Whelk-O®1 

 

The Whelk-O 1 Chiral Stationary Phase is based on 1-(3,5-Dinitrobenzamido)- 1,2,3,4,-tetrahydrophenanthrene. This phase allows separation of racemates from a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, and alcohols.

  • Excellent method development column with applicability to a wide range of compound classes

  • Alternate selectivity to polysaccharide chiral stationary phases

  • Covalently bonded for long term performance and broad mobile phase compatibility

  • Broad range of particle sizes and dimensions for analytical to preparative scale separations

  • High loading capacity for excellent scalability in preparative applications

  • Choice of enantiomeric phases allows inversion of peak elution order

  • Recognized as USP L102

The Whelk-O 1 was originally designed for the separation of underivatized non-steroidal anti-inflammatory drugs (NSAIDs). This π-electron acceptor/π- electron donor phase allows broad selectivity, allowing resolution of a wide variety of underivatized racemates. The broad versatility observed with the Whelk-O 1 column, compares favorably with polysaccharide-derived chiral stationary phases and in many cases offers alternate selectivity. In addition, because of its covalent nature, this chiral phase is compatible with all commonly used mobile phases, including aqueous systems—a distinct advantage over coated polysaccharide chiral stationary phases. Other advantages include column durability, excellent efficiency, elution order inversion, and excellent loading capacity. Whelk-O 1 is available in a full range of particle sizes (1.8-, 3.5-, 5-, 10-, 16-, and 20 μm) to serve small scale analytical separations up to large scale preparative work.

Inversion of elution order on (R,R) and (S,S) Whelk-O 1

Whelk-O 1 columns are available in both R,R and S,S configurations. Choosing one or the other allows for peak elution order to be inverted. This can be beneficial in preparative and process scale applications when needing to elute one peak of interest quickly.

Whelk-O®2 

Whelk-O 2 has the same chiral selector as Whelk-O 1 but incorporates a trifunctional linkage to the silica support. In most cases, the enantioselectivity remains the same as that obtained with Whelk-O 1. Whelk-O 2 was designed to improve the resistance of the stationary phase to hydrolysis while using strong organic modifiers such as trifluoroacetic acid. Whelk-O 2 is ideal for preparative separations since the material is bonded on 10 µm, 100Å spherical Kromasil silica. This allows the preparative chromatographer to perform method development on an analytical column and immediately scale up to larger diameter columns.

AZYP Chiral Columns NEW

NEW!!! AZYP Chiral Phases Offer Unique Selectivity for Difficult Separations

AZYP’s chiral phase chemistries offer a wide range of selectivity's for your most challenging chiral separations.

All phases are bonded to 2.7μm superficially porous particles for faster, highly efficient separations.

  • Complementary selectivity to polysaccharide and brush-type chiral phases.

  • Fast chiral screening and method development.

  • Narrow peak widths improve sensitivity and resolution.

  • Compatible with a broad range of solvents for NPLC, RPLC and SFC.

AZYP Chiral Selectors

  • Beta-cyclodextrin, hydroxypropyl.

  • Teicoplanin.

  • Modified macrocyclic glycopeptide.

  • Vancomycin.

  • Alkyl derivatized cyclofructan CF-6.

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What is Core-shell technology.

Core-shell (superficially porous particles) have a solid silica core, enveloped by a homogenous porous shell. This reduces band broadening and improves efficiency, largely due to more rapid analyte mass transfer – from the mobile phase through the stationary phase and back again. This is because diffusion only occurs in the porous, outer layer of the particle rather than the entire particle. The result is reduced analysis times and higher column efficiencies without generating extreme back-pressures. 

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